Modeling fimbriae mediated parasite–host interactions

Modeling fimbriae mediated parasite-host interactions.

Type 1 fimbriae are a known virulence factor in a number of pathogenic enterobacteriaceae, including Salmonella, Shigella and E. coli. Yet, they are also expressed by some commensal strains, notably of E. coli. One hypothesis of the role of fimbriae in commensals is that they evoke a small but tolerable host immune response in order to have the host release sialic acid, which is a valuable nutr...

Porphyromonas gingivalis minor fimbriae are required for cell-cell interactions.

Two distinctive types of fimbriae have been identified in Porphyromonas gingivalis. In this report, we demonstrate that minor fimbriae are involved in P. gingivalis autoaggregation and colonization. A mutant with a deficiency in minor fimbriae can bind to a saliva-coated surface but does not form microcolonies as the wild-type strain does.

Enterobacterial fimbriae.

Many different species of the family Enterobacteriaceae have been shown to possess fimbrial appendages which emerge from the bacterial cell as straight, rigid organelles distinct from flagella (14). The role of fimbriae (synonym: pili) as adhesins in both enterotoxigenic and uropathogenic isolates of Escherichia coli has been demnonstrated, and thus the identification of such appendages as viru...

Trust in mediated interactions

Contract-Mediated Interorganizational Interactions

Opportunities abound for combining the Internet's many exciting services and resources into new, value-added interorganizational services. Increasingly, such collaborative ventures, or virtual organizations, will encourage strategic alliances among groups of organizations that share services electronically to satisfy mutual business goals. These arrangements allow each organization to maintain ...